Dog ate chocolate?

ask a vet

Trifexis overdose.

Species: Dog
Breed: Chihuahua
Age: 1-2 years
My dog ate 4 tablets of Trifexis today. He seems a little quieter than usual. Should I be worried about Trifexis overdose?




Online vet, Dr. Marie

Dr. Marie replied:

Trifexis is a good medication for flea and heartworm prevention, but it can possibly cause problems if a dog eats too much of it.

We can see toxic effects if a dog ingests more than 400mg/kg of spinosad (one of the ingredients in Trifexis). So, let's assume your chihuahua is 5 lbs. This is the equivalent of 5/2.2 = 2.3kg. This means that if he ingested more than 2.3x400mg = 909mg of Trifexis then I would be worried.

The chihuahua size of Trifexis contains 140mg of spinosad. So, 4 tablets would be 4x140=560mg.

As 560mg is less than the toxic dose for your dog of 909mg, Snarles really should be ok.

There have been some reported cases though of dogs being extra sensitive to Trifexis and having lethargy and reluctance to eat after even a single dose. In severe cases dogs can have seizures. Fortunately these occurrences are rare.

Most of the time, if a dog eats too much Trifexis, they will vomit. Because they have vomited up the medication, it is much less likely that they will keep enough drug in the body to produce side effects.

It sounds like your dog will be ok. However, if he continues to be lethargic or if he has repeated vomiting or tremors/seizures then I would have a vet take a look.

Dr. Marie.


Do you have a pet website? Interested in learning more about SEO for Wix?


Check out our dog age calculator and cat age calculator.

Want to receive pet coupons, vet advice and info on new pet products in your inbox?

* indicates required

We'll only send you great stuff, never spam. Unsubscribe any time.

Disclaimer: Although Dr. Marie is a qualified veterinarian, the information found on this site is not meant to replace the advice of your own veterinarian. AskAVetQuestion.com and Dr. Marie do not accept any responsibility for any loss, damage, injury, death, or disease which may arise from reliance on information contained on this site. Do not use information found on this site for diagnosing or treating your pet. Anything you read here is for information only.

Search for similar questions:

ask a vet

Popular questions...

Chaning cat's thyroid medication. Hi, my cat is 13 and 1/2 years old. He was diagnosted hyperthyorid 2 1/2 months ago.... (7976 views)

Licking foot. In April 2010, I took my 8 year old collie for his yearly shots. About a week later,... (9203 views)

Dog can't jump. My dog keeps shaking and isn't acting herself. Her whole body is shaking but it is... (23293 views)

calamine lotion on dogs Doeden has a itchy rash, raised pale bumps, on the back of his neck; I put on some... (94572 views)

Bad rash on neck. One of our neighborhood cats has a really bad looking rash all over his neck. Here... (17639 views)

Back spasms 2 years ago, I took Rusty to an emergeny vet one evening because he seemed warm and... (18717 views)

Can dog get Hepatitis C? can dogs contract hep c from biting someone that has it? ... (27257 views)

Black sore near anus. Hello Dr.Marie (I am SO grateful for you!), I have had my two dogs (same breeder)... (47848 views)

Dog's penis is stuck out of sheath. Hi, Ive noticed my 7 month male yorkie has started to lick himself a lot "down... (105795 views)

Lentigo on a cat. Hi Dr. Marie... My 3.5 year old tortoiseshell cat has developed a black freckle... (21101 views)

See all questions...

Dr. MarieDr. Marie is a veterinarian who practices in a busy animal hospital in Ottawa, Ontario. She created Ask A Vet Question as a resource for good, accurate veterinary advice online. Dr. Marie treats dogs, cats, hamsters, guinea pigs, and rats. She has been a vet since 1999.

Is an online vet visit just as good as a trip to your veterinarian? No! But, many times, asking an online veterinarian a question can help save you money. While Dr. Marie can't officially diagnose your pet or prescribe medications, she can often advise you on whether a vet visit is necessary. You can also ask Dr. Marie for a second opinion on your pet's condition.