Dog ate chocolate?

ask a vet

Heartworm and MDR1

Species: Dog
Breed: 1. Aussie, 2. Lassie
Age: 2-5 years
I rrecently had both dogs genotyped for MDR1 mutation and both are positive. Bella is mutant/mutant, Khodi Normal /mutant. Isabella especially get very sick on heartguard and both are mildly on advantix. Ivermectin, Milbemycin, Selamectin and Moxidectin are all on the list of drug sensitivities for MDR1 positive dogs. What can I use for heart worm prevention?

Need help finding a veterinarian in your area? Click here for Dr. Marie's advice on
finding a good veterinarian near you.
 

Online vet, Dr. Marie

Dr. Marie replied:

Ultimately this is a question that needs to be answered by your vet as they are aware of which heartworm medications are the most effective in your area.

However, all of the products that you have mentioned are considered safe for dogs with an MRD1 mutation. Even though they contain a tiny amount of ivermectin or a derivative of ivermectin it has been shown to be extremely safe at the dosages contained in these drugs.

I wrote an article that discusses her these dosages and what is safe for these dogs by with an MDR1 mutation.

What kind of reaction do the dogs have? If dogs are reacting to ivermectin the reaction is usually a neurological one. You can see tremors and twitching and things like that. If that is not what you were seeing then there may be something other than ivermectin sensitivity going on.

Unfortunately, I am not aware of an alternative for you.

Dr. Marie



Check out our dog age calculator and cat age calculator.

QUIZ: Is your cat secretly planning to murder you?


Disclaimer: Although Dr. Marie is a qualified veterinarian, the information found on this site is not meant to replace the advice of your own veterinarian. AskAVetQuestion.com and Dr. Marie do not accept any responsibility for any loss, damage, injury, death, or disease which may arise from reliance on information contained on this site. Do not use information found on this site for diagnosing or treating your pet. Anything you read here is for information only.
Have you tried the Purr Pillow? This is one of Dr. Marie's top recommended pet products for 2016.

Search for similar questions:

ask a vet

Popular questions...

Wobbly Boxer. My 3 year old boxer has been having some issues. He has always been very very clumsy... (7492 views)

How often to give Benadryl? Lola always has a little bit of a breathing issue b/c of her short snout and I have... (5099 views)

Unexplained liver problems. Dr. Marie, I have a now 14 year old yorkie with some complex medical issues and... (3582 views)

Coughing puppy. My 3 month old puppy is trying to hack/cough up as if she has something stuck in... (8030 views)

Natural flea product? Dear Dr. Marie: We use Sentry Natural Defense squeeze-on flea control product on... (6077 views)

Dental problems in 20 year old cat. My cat Jack, who is 20 yrs old and has a predominant heart murmur and obviously a... (9039 views)

Cat is dying. I took in a stray that was living in a garage since his was little for years and was... (3838 views)

Ear Cleaning. I'd like to know is a vinegar and water solution a good home remedy for my dogs... (19793 views)

Dog ate duck bones. Hi Dr. Marie, Poppy nipped one piece of cooked duck wing bone 2 days ago at lunch... (10173 views)

Red spot on dog's neck. I just noticed a red spot on my pug. I will try to attach a picture. It's on his... (7481 views)

See all questions...

Dr. MarieDr. Marie is a veterinarian who practices in a busy animal hospital in Ottawa, Ontario. She created Ask A Vet Question as a resource for good, accurate veterinary advice online. Dr. Marie treats dogs, cats, hamsters, guinea pigs, and rats. She has been a vet since 1999.

Is an online vet visit just as good as a trip to your veterinarian? No! But, many times, asking an online veterinarian a question can help save you money. While Dr. Marie can't officially diagnose your pet or prescribe medications, she can often advise you on whether a vet visit is necessary. You can also ask Dr. Marie for a second opinion on your pet's condition.