Dog ate chocolate?

ask a vet

Phenobarbital and Zonisamide.

Species: Dog
Breed: miniature poodle
Age: 5-8 years
Ziggy had cluster seizures as a puppy and we have been controlling them (averages 1/month) with a combination of Phenobarbital and Potassium Bromide. His latest Bile Acid level was 45.1, up from 27.6 six months ago. His ALP and GGT levels have always been high according to my vet because of the phen barb.
He has recommended we transition him off the phen barb and on to 100 mg Zonisamide taking them both as we taper off the phen barb slowly.
Does this sound like a good idea to you or should we have further tests done to verify the most recent Bile Acid test and/or liver damage? He has a bad tooth to deal with at the same time. Can a decaying tooth effect the Bile Acid level?
We are planning on taking care of the tooth first then dealing with the medication transition. The last time he had a tooth removed he had his worst seizure to date.
Would love your opinion on this. Thank you.


Online vet, Dr. Marie

Dr. Marie replied:

I'm sorry to hear about Ziggy's recent problems. Seizures can be very frustrating to deal with. A bile acid level of 45.1 does indeed sound high. High bile acids can often be a sign that the liver function is impaired, and as we know that phenobarbital can be hard on the liver, it's not wise to stay on it if there is risk of liver damage. There is certainly no harm in asking your vet to repeat the bile acids test as occasionally we can get misleading results.

But, it does sound like your vet is doing the same things that I would do.

It's unlikely that a dental issue would affect the bile acids, so I wouldn't think that this is the problem.

If you do transition the medications (which sounds like the wise things to do) I hope things go well.

Dr. Marie.


Do you have a pet website? Interested in learning more about SEO for Wix?


Check out our dog age calculator and cat age calculator.

Want to receive pet coupons, vet advice and info on new pet products in your inbox?

* indicates required

We'll only send you great stuff, never spam. Unsubscribe any time.

Disclaimer: Although Dr. Marie is a qualified veterinarian, the information found on this site is not meant to replace the advice of your own veterinarian. AskAVetQuestion.com and Dr. Marie do not accept any responsibility for any loss, damage, injury, death, or disease which may arise from reliance on information contained on this site. Do not use information found on this site for diagnosing or treating your pet. Anything you read here is for information only.

Search for similar questions:

ask a vet

Popular questions...

Vomiting yellow liquid. Maynard has been vomiting up yellowish urine colored liquid a few time in the last... (9200 views)

Paraneoplastic syndrome? In 3/2013 after suffering 2 "seizures," Clark was diagnosed with insulinoma from... (6951 views)

Golden Retriever Losing Weight. Hi my dog is 13 years old ,and tough he acts fine ,and goes walking everyday,he has... (17227 views)

Small puppy. Rnt? Hi, I just purchased a purebred BullMastiff puppy. He is very happy and seems to... (30156 views)

Grief after dog's death. I need your help, please... for peace of mind so I can sleep and live with myself. ... (10882 views)

Older dog losing weight. I have Sheppard/Lab mixed breed about 13 years old. She is a large dog and has been... (76722 views)

TPO success rate. WHat is the degree of success from triple... (8630 views)

Raw, sore nose. Hi there I have a 5 year old Malamute named Mika about a year ago she was attatcked... (9155 views)

Did Orbax cause diarrhea? Hi Dr Marie, it's me again regarding Bandit, my 4 yr old DSH. I had e-mailed you... (10471 views)

Pain in stomatitis after extractions. 9 year old cat has stomatitis. She is NOT FIV positive. She has had all her teeth... (19893 views)

See all questions...

Dr. MarieDr. Marie is a veterinarian who practices in a busy animal hospital in Ottawa, Ontario. She created Ask A Vet Question as a resource for good, accurate veterinary advice online. Dr. Marie treats dogs, cats, hamsters, guinea pigs, and rats. She has been a vet since 1999.

Is an online vet visit just as good as a trip to your veterinarian? No! But, many times, asking an online veterinarian a question can help save you money. While Dr. Marie can't officially diagnose your pet or prescribe medications, she can often advise you on whether a vet visit is necessary. You can also ask Dr. Marie for a second opinion on your pet's condition.